Preclinical pharmacokinetic studies and prediction of human PK profiles for Deg-AZM, a clinical-stage new transgelin agonist

• Asıl Yazarlar: Xiaoting Gu (Yazar), Xiaohe Li (Yazar), Weixue Tian (Yazar), Chaoyue Zheng (Yazar), Yutian Cai (Yazar), Xiang Xu (Yazar), Conglu Zhao (Yazar), Hongting Liu (Yazar), Yao Sun (Yazar), Zhilin Luo (Yazar), Shuwen Zhu (Yazar), Honggang zhou (Yazar), Xiaoyu Ai (Yazar), Cheng Yang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

IntroductionDeglycosylated azithromycin (Deg-AZM), a newly developed Class I drug with good therapeutic effects on slow transit constipation, is a small-molecule transgelin agonist that has been approved for clinical trials in 2024. The preclinical pharmacokinetic profile of Deg-AZM was investigated...