Hypomethylation of the c-myc promoter region induced by phenobarbital in rat liver

• Main Authors: Katarzyna Urbanek-Olejnik (Author), Monika Liszewska (Author), Alicja Winczura (Author), Agnieszka Hernik (Author), Paweł Struciński (Author), Jan K. Ludwicki (Author)
• Format: Book
• Published: National Institute of Public Health - National Institute of Hygiene, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. The changes in DNA methylation are considered as one of the early events in hepatocarcinogenesis. Objective. We evaluated the ability of phenobarbital (PB) - the most widely used anticonvulsant worldwide and classical rodent liver carcinogen - to cause the promoter region of the c-myc pr...