Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis

• Main Authors: Michael Horckmans (Author), Esteban Diaz Villamil (Author), Céline Verdier (Author), Henrik Laurell (Author), Jean-Bernard Ruidavets (Author), Lucas De Roeck (Author), Guillaume Combes (Author), Laurent O. Martinez (Author), Didier Communi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human P2Y4 is a UTP receptor, while in mice it is activated by both ATP and UTP. P2Y4 knockout (KO) in mice protects against myocardial infarction and is characterized by increased adiponectin secretion by adipocytes, and decreased cardiac inflammation and permeability under ischemic conditions. The...