Cover Image

An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cells

Objective: Human embryonic stem cell (hESC; SC)-derived pancreatic β cells can be used to study diabetes pathologies and develop cell replacement therapies. Although current differentiation protocols yield SCβ cells with varying degrees of maturation, these cells still differ from deceased donor hum...

Full description

Saved in:

Bibliographic Details
Main Authors:	Carmen L. Bayly (Author), Xiao-Qing Dai (Author), Cuilan Nian (Author), Paul C. Orban (Author), C. Bruce Verchere (Author), Patrick E. MacDonald (Author), Francis C. Lynn (Author)
Format:	Book
Published:	Elsevier, 2024-11-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition
by: Alexis Z.L. Shih, et al.
Published: (2022)

miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation
by: Javier López-Beas, et al.
Published: (2018)

Generation of Insulin-Producing Cells from Canine Adipose Tissue-Derived Mesenchymal Stem Cells
by: Takahiro Teshima, et al.
Published: (2020)

Oligomannuronate prevents mitochondrial dysfunction induced by IAPP in RINm5F islet cells by inhibition of JNK activation and cell apoptosis
by: Xi Liu, et al.
Published: (2020)

In-vitro Differentiation of Human Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells to Insulin-Producing Cells
by: Masoomeh Nekohi Madoei, et al.
Published: (2015)

Efficiency of Stem Cell (SC) Differentiation into Insulin-Producing Cells for Treating Diabetes: a Systematic Review
by: Marzieh Nemati, et al.
Published: (2021)

Repression of COUP-TFI Improves Bone Marrow-Derived Mesenchymal Stem Cell Differentiation into Insulin-Producing Cells
by: Tao Zhang, et al.
Published: (2017)

Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway
by: Jianzhen Lin, et al.
Published: (2019)

SENP2 is vital for optimal insulin signaling and insulin-stimulated glycogen synthesis in human skeletal muscle cells
by: Jenny Lund, et al.
Published: (2021)

Transfection of Peripheral Blood Monocytes with SOX2 Enhances Multipotency, Proliferation, and Redifferentiation into Neohepatocytes and Insulin-Producing Cells
by: Ayman Hyder, et al.
Published: (2018)

Three-Dimensional Culture Promotes the Differentiation of Human Dental Pulp Mesenchymal Stem Cells Into Insulin-Producing Cells for Improving the Diabetes Therapy
by: Bingbing Xu, et al.
Published: (2020)

Continuous Inhibition of Sonic Hedgehog Signaling Leads to Differentiation of Human-Induced Pluripotent Stem Cells into Functional Insulin-Producing β Cells
by: Song Lee, et al.
Published: (2021)

Retraction Note: MiR-140 targets RAP2A to enable the proliferation of insulin-treated ovarian granulosa cells
by: Zhengfang Xiong, et al.
Published: (2023)

RETRACTED ARTICLE: MiR-140 targets RAP2A to enable the proliferation of insulin-treated ovarian granulosa cells
by: Zhengfang Xiong, et al.
Published: (2020)

History of insulin
by: Celeste C. Quianzon, et al.
Published: (2012)

FITC labeling of human insulin and transport of FITC-insulin conjugates through MDCK cell monolayer
by: Darshana Shah, et al.
Published: (2019)

Cell Adhesive Character of Phenylboronic Acid-Modified Insulin and Its Potential as Long-Acting Insulin
by: Yui Ohno, et al.
Published: (2019)

Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion
by: Mahmoud El Azzouny, et al.
Published: (2016)

Selective Modification of Streptozotocin at the C3 Position to Improve Its Bioactivity as Antibiotic and Reduce Its Cytotoxicity towards Insulin-Producing β Cells
by: Ji Zhang, et al.
Published: (2020)

The dynamic plasticity of insulin production in β-cells
by: Brandon B. Boland, et al.
Published: (2017)

Dual effect of reduced type I diacylglycerol kinase activity on insulin secretion from MIN6 β-cells
by: Toshiaki Sawatani, et al.
Published: (2019)

The insulin signaling pathway is dysregulated in cumulus cells from obese, infertile women with polycystic ovarian syndrome with an absence of clinical insulin resistance
by: Mauricio B. Chehin, et al.
Published: (2020)

An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation
by: Tamara Casteels, et al.
Published: (2021)

Correlation between Insulin-Like Growth Factor I and Skeletal Maturity Indicators
by: Julia Carelli DDS, MSc, et al.
Published: (2021)

Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 - Biomarkers for Skeletal Maturity Assessment in Class II Malocclusion
by: Arif Yezdani, et al.
Published: (2024)

Insulin therapy waste produced in the households of people with diabetes monitored in Primary Care
by: Gilmara Holanda da Cunha, et al.

Concentrated insulins: the new basal insulins
by: Lamos EM, et al.
Published: (2016)

Coventional insulin versus insulin analogs
by: Anil Gomber, et al.
Published: (2019)

Cotransplantation of Adipose Tissue-Derived Insulin-Secreting Mesenchymal Stem Cells and Hematopoietic Stem Cells: A Novel Therapy for Insulin-Dependent Diabetes Mellitus
by: A. V. Vanikar, et al.
Published: (2010)

Osteocalcin and serum insulin-like growth factor-1 as biochemical skeletal maturity indicators
by: Tulika Tripathi, et al.
Published: (2017)

Reprogramming of Pancreatic Exocrine Cells AR42J Into Insulin-producing Cells Using mRNAs for Pdx1, Ngn3, and MafA Transcription Factors
by: Tomas Koblas, et al.
Published: (2016)

Transcriptional response of endometrial cells to insulin, cultured using microfluidics
by: Soo Young Baik, et al.
Published: (2023)

JNK at the crossroad of obesity, insulin resistance, and cell stress response
by: Giovanni Solinas, et al.
Published: (2017)

ROCK1 regulates insulin secretion from β-cells
by: Byung-Jun Sung, et al.
Published: (2022)

Insulin regulates human pancreatic endocrine cell differentiation in vitro
by: Perla Cota, et al.
Published: (2024)

Investigating the potential role of swertiamarin on insulin resistant and non-insulin resistant granulosa cells of poly cystic ovarian syndrome patients
by: Muskaan A. Belani, et al.
Published: (2023)

Insulin-derived amyloidosis: The insulin ball, amyloidoma
by: Curt Samlaska, MD, et al.
Published: (2020)

Insulin receptor trafficking steers insulin action
by: Simone Hausmann, et al.
Published: (2016)

Fast-tracking antibody maturation using a B cell-based display system
by: Hitomi Masuda, et al.
Published: (2022)

A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila
by: Laura Palanker Musselman, et al.
Published: (2011)