2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity

• Main Authors: Juan Martín-López (Author), Sandra Codony (Author), Clara Bartra (Author), Christophe Morisseau (Author), María Isabel Loza (Author), Coral Sanfeliu (Author), Bruce D. Hammock (Author), José Brea (Author), Santiago Vázquez (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of endogenous epoxyeicosatrienoic acids. Numerous potent sEH inhibitors (sEHI) have been developed, however many c...