Artemisinin Derivatives Target Topoisomerase 1 and Cause DNA Damage in Silico and in Vitro

• Main Authors: Onat Kadioglu (Author), Ariel Chan (Author), Alena Cong Ling Qiu (Author), Vincent Kam Wai Wong (Author), Vanessa Colligs (Author), Sabine Wecklein (Author), Halima Freund-Henni Rached (Author), Thomas Efferth (Author), Wen-Luan Wendy Hsiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA topoisomerases 1 and 2 are enzymes that maintain DNA topology and play important essential genome functions, including DNA replication and transcription. Aberrant topoisomerases cause genome instability and a wide range of diseases, cancer in particular. Both Topo 1 and 2 are the targets of valu...