Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly

• Main Authors: Mercè Farràs (Author), Joan Miret (Author), Marc Camps (Author), Ramón Román (Author), Óscar Martínez (Author), Xavier Pujol (Author), Stéphane Erb (Author), Anthony Ehkirch (Author), Sarah Cianferani (Author), Antoni Casablancas (Author), Jordi Joan Cairó (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite advances in medical care, cancer remains a major threat to human health. Antibody-drug conjugates (ADCs) are a promising targeted therapy to overcome adverse side effects to normal tissues. In this field, the current challenge is obtaining homogeneous preparations of conjugates, where a defi...