Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes

• Main Authors: Zhongcheng Liu (Author), Yuchen Tang (Author), Liangzhi He (Author), Bin Geng (Author), Fan Lu (Author), Jinwen He (Author), Qiong Yi (Author), Xuening Liu (Author), Kun Zhang (Author), Lifu Wang (Author), Yayi Xia (Author), Jin Jiang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Piezo1, a mechanosensitive ion channel, participates in a variety of biological processes in maintaining bone homeostasis. As the most abundant cells in bones of the mammals, osteocytes play an essential role in bone formation, remodeling, and bone mass maintenance. Here, by exposing MLO-Y4 osteocyt...