Pharmacogenomic-guided clozapine administration based on HLA-DQB1, HLA-B and SLCO1B3-SLCO1B7 variants: an effectiveness and cost-effectiveness analysis

The identification of pharmacogenetic factors that increase the susceptibility to clozapine-induced agranulocytosis or granulocytopenia (CIAG) has received increasing interest. The SLCO1B3-SCLO1B7 variant (rs149104283) and single amino acid changes in human leukocyte antigen (HLA) HLA-DQB1 (126Q) an...

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Main Authors: Kohei Ninomiya (Author), Takeo Saito (Author), Masashi Ikeda (Author), Nakao Iwata (Author), François R. Girardin (Author)
Format: Book
Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
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3rd Floor Main Library

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