UDP-Induced Phagocytosis and ATP-Stimulated Chemotactic Migration Are Impaired in STIM1−/− Microglia In Vitro and In Vivo

• Main Authors: Hye Min Lim (Author), Heo Woon (Author), Jung Woo Han (Author), Yoshihiro Baba (Author), Tomohiro Kurosaki (Author), Min Goo Lee (Author), Joo Young Kim (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

STIM1 is the only currently known intracellular calcium sensor that functions as the calcium influx regulator controlling immune cell activation. STIM1 function in immune cell calcium signalling has been studied extensively; however, its role in microglia, innate immune cells in brain, has not been...