The degradation of poloxamer 188 in buffered formulation conditions

The degradation of poloxamer 188 in buffered formulation conditions

Abstract Poloxamer 188 (P188) as a non-ionic surfactant is used in proteinaceous formulations to prevent protein adsorption to hydrophobic surfaces and unfolding at interfaces, preventing the formation of aggregates and particles. Its chemical intactness is crucial to the stability of drug products...

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Main Authors: Wei Chen (Author), Siegfried Stolz (Author), Vincent Wegbecher (Author), Dixy Parakkattel (Author), Christina Haeuser (Author), Nuria Sancho Oltra (Author), Ravuri S. K. Kishore (Author), Steven Bond (Author), Christian Bell (Author), Robert Kopf (Author)
Format: Book
Published: SpringerOpen, 2022-03-01T00:00:00Z.
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