Atria Selective Prolongation by NIP-142, an Antiarrhythmic Agent, of Refractory Period and Action Potential Duration in Guinea Pig Myocardium

• Main Authors: Tomoyuki Matsuda (Author), Kentaro Takeda (Author), Mie Ito (Author), Reiko Yamagishi (Author), Miku Tamura (Author), Hideki Nakamura (Author), Noriko Tsuruoka (Author), Tomoaki Saito (Author), Haruko Masumiya (Author), Takeshi Suzuki (Author), Naoko Iida-Tanaka (Author), Maho Itokawa-Matsuda (Author), Toru Yamashita (Author), Nobutomo Tsuruzoe (Author), Hikaru Tanaka (Author), Koki Shigenobu (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NIP-142 is a novel benzopyran compound that was shown to prolong the atrial effective refractory period and terminate experimental atrial fibrillation in the dog. In the present study, we examined the effects of NIP-142 on isolated guinea pig myocardium and on the G-protein-coupled inwardly rectifyi...