INCREASING SENSITIVITY OF MCF-7/DOX CELLS TOWARDS DOXORUBICIN BY HESPERETIN THROUGH SUPPRESSION OF P-GLYCOPROTEIN EXPRESSION

• المؤلفون الرئيسيون: Sarmoko (مؤلف), Dyaningtyas Dewi Pamungkas Putri (مؤلف), Ratna Asmah Susidarti (مؤلف), Agung Endro Nugroho (مؤلف), Edy Meiyanto (مؤلف)
• التنسيق: كتاب
• منشور في: Universitas Gadjah Mada, 2014-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Long-term use of doxorubicin causes cancer resistance due to overexpression of P-glycoprotein (P-gp), a protein that plays a role in cell drug efflux. The purpose of this study is to determine the action of hesperetin in increasing the cytotoxicity of doxorubicin on MCF-7 cancer cells resistant to d...