INCREASING SENSITIVITY OF MCF-7/DOX CELLS TOWARDS DOXORUBICIN BY HESPERETIN THROUGH SUPPRESSION OF P-GLYCOPROTEIN EXPRESSION

• Main Authors: Sarmoko (Author), Dyaningtyas Dewi Pamungkas Putri (Author), Ratna Asmah Susidarti (Author), Agung Endro Nugroho (Author), Edy Meiyanto (Author)
• Format: Book
• Published: Universitas Gadjah Mada, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Long-term use of doxorubicin causes cancer resistance due to overexpression of P-glycoprotein (P-gp), a protein that plays a role in cell drug efflux. The purpose of this study is to determine the action of hesperetin in increasing the cytotoxicity of doxorubicin on MCF-7 cancer cells resistant to d...