INCREASING SENSITIVITY OF MCF-7/DOX CELLS TOWARDS DOXORUBICIN BY HESPERETIN THROUGH SUPPRESSION OF P-GLYCOPROTEIN EXPRESSION

• 主要な著者: Sarmoko (著者), Dyaningtyas Dewi Pamungkas Putri (著者), Ratna Asmah Susidarti (著者), Agung Endro Nugroho (著者), Edy Meiyanto (著者)
• フォーマット: 図書
• 出版事項: Universitas Gadjah Mada, 2014-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Long-term use of doxorubicin causes cancer resistance due to overexpression of P-glycoprotein (P-gp), a protein that plays a role in cell drug efflux. The purpose of this study is to determine the action of hesperetin in increasing the cytotoxicity of doxorubicin on MCF-7 cancer cells resistant to d...