Can small drugs predict the intrinsic aqueous solubility of 'beyond Rule of 5' big drugs?

The aim of the study was to explore to what extent small molecules (mostly from the Rule of 5 chemical space) can be used to predict the intrinsic aqueous solubility, S0, of big molecules from beyond the Rule of 5 (bRo5) space. It was demonstrated that the General Solubility Equation (GSE) and the A...

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Main Authors: Alex Avdeef (Author), Manfred Kansy (Author)
格式: 圖書
出版: International Association of Physical Chemists (IAPC), 2020-04-01T00:00:00Z.
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索引號: A1234.567
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