TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2

• Main Authors: Yali Fan (Author), Shuya Chen (Author), Chunfang Chu (Author), Xiaodan Yin (Author), Jing Jin (Author), Lingyan Zhang (Author), Huihui Yan (Author), Zheng Cao (Author), Ruixia Liu (Author), Mingwei Xin (Author), Lin Li (Author), Chenghong Yin (Author)
• Format: Book
• Published: BMC, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Premature ovarian insufficiency (POI) is a severe disorder leading to female infertility. Genetic mutations are important factors causing POI. TP63-truncating mutation has been reported to cause POI by increasing germ cell apoptosis, however what factors mediate this apoptosis re...