In vitro, in vivo, and in silico approaches for evaluating the preclinical DMPK profiles of ammoxetine, a novel chiral serotonin and norepinephrine reuptake inhibitor

Background and AimAmmoxetine, a novel chiral serotonin and norepinephrine reuptake inhibitor, holds promise for major depressive disorder treatment. This study aimed to thoroughly investigate its preclinical drug metabolism and pharmacokinetics (DMPK) profiles.MethodsThe preclinical DMPK profiles of...

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Main Authors: Xiuqing Zhu (Author), Yuexin Li (Author), Huan Luo (Author), Yunxia Zhang (Author), Zhenqing Zhang (Author), Jinglai Li (Author)
Format: Book
Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
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