Use systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans

• Главные авторы: Yasong eLu (Автор), Steven C Griffen (Автор), David W Boulton (Автор), Tarek A Leil (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2014-12-01T00:00:00Z.
• Предметы: article
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In the kidney, glucose in glomerular filtrate is reabsorbed primarily by sodium-glucose cotransporters 1 (SGLT1) and 2 (SGLT2) along the proximal tubules. SGLT2 has been characterized as a high capacity, low affinity pathway responsible for reabsorption of the majority of filtered glucose in the ear...