Use systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans

• Main Authors: Yasong eLu (Author), Steven C Griffen (Author), David W Boulton (Author), Tarek A Leil (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2014-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

In the kidney, glucose in glomerular filtrate is reabsorbed primarily by sodium-glucose cotransporters 1 (SGLT1) and 2 (SGLT2) along the proximal tubules. SGLT2 has been characterized as a high capacity, low affinity pathway responsible for reabsorption of the majority of filtered glucose in the ear...