Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine

• Main Authors: Leslie L. Glass (Author), Fernando J. Calero-Nieto (Author), Wajid Jawaid (Author), Pierre Larraufie (Author), Richard G. Kay (Author), Berthold Göttgens (Author), Frank Reimann (Author), Fiona M. Gribble (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: To identify sub-populations of intestinal preproglucagon-expressing (PPG) cells producing Glucagon-like Peptide-1, and their associated expression profiles of sensory receptors, thereby enabling the discovery of therapeutic strategies that target these cell populations for the treatment...