Homologous recombination deficiency is inversely correlated with microsatellite instability and identifies immunologically cold tumors in most cancer types

• Main Authors: Jan Budczies (Author), Klaus Kluck (Author), Susanne Beck (Author), Iordanis Ourailidis (Author), Michael Allgäuer (Author), Michael Menzel (Author), Daniel Kazdal (Author), Lukas Perkhofer (Author), Alexander Kleger (Author), Peter Schirmacher (Author), Thomas Seufferlein (Author), Albrecht Stenzinger (Author)
• Format: Book
• Published: Wiley, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Homologous recombination deficiency (HRD) leads to DNA double‐strand breaks and can be exploited by the use of poly (ADP‐ribose) polymerase (PARP) inhibitors to induce synthetic lethality. Extending the original therapeutic concept, the role of HRD is currently being investigated in clinica...