Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons

• Main Authors: Katherina Beck (Author), Nadine Ehmann (Author), Till F. M. Andlauer (Author), Dmitrij Ljaschenko (Author), Katrin Strecker (Author), Matthias Fischer (Author), Robert J. Kittel (Author), Thomas Raabe (Author)
• Format: Book
• Published: The Company of Biologists, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Plastic changes in synaptic properties are considered as fundamental for adaptive behaviors. Extracellular-signal-regulated kinase (ERK)-mediated signaling has been implicated in regulation of synaptic plasticity. Ribosomal S6 kinase 2 (RSK2) acts as a regulator and downstream effector of ERK. In th...