Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis

• Main Authors: Jiyu Zhou (Author), Ningning Huang (Author), Yitong Guo (Author), Shuang Cui (Author), Chaoliang Ge (Author), Qingxian He (Author), Xiaojie Pan (Author), Guangji Wang (Author), Hong Wang (Author), Haiping Hao (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obeticholic acid (OCA), the first FXR-targeting drug, has been claimed effective in the therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be effective against liver fibrosis, possibly due to the lower dosage to reduce the incidence of the side-effect of pruritus...