Protection Against Dopaminergic Neurodegeneration in Parkinson's Disease-Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson's Disease-Linked PARK7

• Hauptverfasser: Masatoshi Inden (Verfasst von), Yoshihisa Kitamura (Verfasst von), Kazunori Takahashi (Verfasst von), Kazuyuki Takata (Verfasst von), Natsuko Ito (Verfasst von), Rina Niwa (Verfasst von), Risa Funayama (Verfasst von), Kaneyasu Nishimura (Verfasst von), Takashi Taniguchi (Verfasst von), Toshio Honda (Verfasst von), Takahiro Taira (Verfasst von), Hiroyoshi Ariga (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2011-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract.: DJ-1, Parkinson's disease PARK7, acts as an oxidative stress sensor in neural cells. Recently, we identified the DJ-1 modulator UCP0054278 by in silico virtual screening. However, the effect of the peripheral administration of UCP0054278 on an in vivo Parkinson's disease (PD) mo...