Protection Against Dopaminergic Neurodegeneration in Parkinson's Disease-Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson's Disease-Linked PARK7

• Main Authors: Masatoshi Inden (Author), Yoshihisa Kitamura (Author), Kazunori Takahashi (Author), Kazuyuki Takata (Author), Natsuko Ito (Author), Rina Niwa (Author), Risa Funayama (Author), Kaneyasu Nishimura (Author), Takashi Taniguchi (Author), Toshio Honda (Author), Takahiro Taira (Author), Hiroyoshi Ariga (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: DJ-1, Parkinson's disease PARK7, acts as an oxidative stress sensor in neural cells. Recently, we identified the DJ-1 modulator UCP0054278 by in silico virtual screening. However, the effect of the peripheral administration of UCP0054278 on an in vivo Parkinson's disease (PD) mo...