Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells

• Main Authors: Tsuruta James K (Author), Richardson Richard T (Author), Alekseev Oleg M (Author), O'Rand Michael G (Author)
• 格式: 图书
• 出版: BMC, 2011-04-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>NASP (Nuclear Autoantigenic Sperm Protein) is a histone chaperone that is present in all dividing cells. NASP has two splice variants: tNASP and sNASP. Only cancer, germ, transformed, and embryonic cells have a high level of expressi...