Comprehensive analysis of clinical Burkholderia pseudomallei isolates demonstrates conservation of unique lipid A structure and TLR4-dependent innate immune activation.

• Main Authors: Sineenart Sengyee (Author), Sung Hwan Yoon (Author), Suporn Paksanont (Author), Thatcha Yimthin (Author), Vanaporn Wuthiekanun (Author), Direk Limmathurotsakul (Author), T Eoin West (Author), Robert K Ernst (Author), Narisara Chantratita (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Burkholderia pseudomallei is an environmental bacterium that causes melioidosis, a major community-acquired infection in tropical regions. Melioidosis presents with a range of clinical symptoms, is often characterized by a robust inflammatory response, may relapse after treatment, and results in hig...