Design, synthesis, biological evaluation, and nitric-oxide release studies of a novel series of celecoxib prodrugs possessing a nitric-oxide donor moiety

A new group of hybrid nitric oxide-releasing anti-inflammatory drugs (NONO-coxibs), in which an O 2-acetoxymethyl-1-(N-ethyl-N-methylamino)diazen-1-ium-1,2-diolate NO-donor moiety is attached directly to the carboxylic acid group of 1-(4-aminosulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids (6a-...

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Hoofdauteurs: Wael Mohamed Soliman (Auteur), Khaled Rashad Ahmed Abdellatif (Auteur), Edward Elmer Knaus (Auteur)
Formaat: Boek
Gepubliceerd in: Universidade de São Paulo, 2019-04-01T00:00:00Z.
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3rd Floor Main Library

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Plaatsingsnummer: A1234.567
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