The impact of forced degradation conditions on mAb dimer formation and subsequent influence on aggregation propensity

• 主要な著者: Michael J. Knight (著者), Léontine Floret (著者), Nisha Patel (著者), John O'Hara (著者), Elizabeth Rodriguez (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Monoclonal antibody (mAb) aggregation can present major challenges for the development of biotherapeutics. An understanding of the molecular mechanisms of mAb aggregation is highly desirable both because it allows the performance of informed risk assessments regarding the criticality of mAb aggregat...