Ranolazine as an Alternative Therapy to Flecainide for SCN5A V411M Long QT Syndrome Type 3 Patients

• Main Authors: Jordi Cano (Author), Esther Zorio (Author), Andrea Mazzanti (Author), Miguel Ángel Arnau (Author), Beatriz Trenor (Author), Silvia G. Priori (Author), Javier Saiz (Author), Lucia Romero (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The prolongation of the QT interval represents the main feature of the long QT syndrome (LQTS), a life-threatening genetic disease. The heterozygous SCN5A V411M mutation of the human sodium channel leads to a LQTS type 3 with severe proarrhythmic effects due to an increase in the late component of t...