Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities
In the current study, virtual screening of a small library of 1302 pyrrolizines bearing urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated for their cytotoxicity against three cancer (MCF-7, A2780, and HT29) and one normal (MRC-5) cell lines. The results of the...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , |
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| التنسيق: | كتاب |
| منشور في: |
Taylor & Francis Group,
2021-01-01T00:00:00Z.
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| الموضوعات: | |
| الوصول للمادة أونلاين: | Connect to this object online. |
| الوسوم: |
إضافة وسم
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الانترنت
Connect to this object online.3rd Floor Main Library
| رقم الاستدعاء: |
A1234.567 |
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| النسخة 1 | متاح |