Pharmacokinetics/pharmacodynamics of L‐ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes

• Main Authors: Rifaat Safadi (Author), Robert S. Rahimi (Author), Dominique Thabut (Author), Jasmohan S. Bajaj (Author), Kalyan Ram Bhamidimarri (Author), Nikolaos Pyrsopoulos (Author), Amy Potthoff (Author), Stan Bukofzer (Author), Laurene Wang (Author), Khurram Jamil (Author), Krishna R. Devarakonda (Author)
• Format: Book
• Published: Wiley, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Hepatic encephalopathy (HE) is a serious neurocognitive complication of liver dysfunction, often associated with elevated plasma ammonia. Ornithine phenylacetate (OP), a potent ammonia scavenger, is being evaluated for the treatment of acute/overt HE. The pharmacokinetics and pharmacodynami...