G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases

• Main Authors: Shengnan Shen (Author), Qiwen Liao (Author), Liwei Gu (Author), Yongping Zhu (Author), Yanqing Liu (Author), Xinwei Zhang (Author), Junzhe Zhang (Author), Qiaoli Shi (Author), Yuxiang Sun (Author), Jigang Wang (Author), Ligen Lin (Author)
• 格式: 图书
• 出版: Compuscript Ltd, 2024-03-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity. GPCRs crosstalk with several transducers, including heterotrimeric G proteins, GPCR kinases (GRKs), and β-arrestins. GPCR-biased agonism has raised the potential of no...