Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice

• Main Authors: Jia Li (Author), Yiting Liu (Author), Jinxia He (Author), Zixuan Wu (Author), Fang Wang (Author), Jian Huang (Author), Liping Zheng (Author), Tao Luo (Author)
• Format: Book
• Published: BMC, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Purpose PAQR7 plays a key role in cell apoptosis as a progesterone membrane receptor. The physiological mechanism of PAQR7 in ovarian function and its anti-apoptotic action in mammals remain poorly understood. Methods We first added 0.2 µM aminoglutethimide (AG), an inhibitor of endogenous...