Intron-derived small RNAs for silencing viral RNAs in mosquito cells.

• Main Authors: Priscilla Y L Tng (Author), Leonela Z Carabajal Paladino (Author), Michelle A E Anderson (Author), Zach N Adelman (Author), Rennos Fragkoudis (Author), Rob Noad (Author), Luke Alphey (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aedes aegypti and Ae. albopictus are the main vectors of mosquito-borne viruses of medical and veterinary significance. Many of these viruses have RNA genomes. Exogenously provided, e.g. transgene encoded, small RNAs could be used to inhibit virus replication, breaking the transmission cycle. We tes...