Crimean-Congo hemorrhagic fever virus strains Hoti and Afghanistan cause viremia and mild clinical disease in cynomolgus monkeys.

• Main Authors: Robert W Cross (Author), Abhishek N Prasad (Author), Viktoriya Borisevich (Author), Joan B Geisbert (Author), Krystle N Agans (Author), Daniel J Deer (Author), Karla A Fenton (Author), Thomas W Geisbert (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Development of vaccines and therapies against Crimean-Congo hemorrhagic fever virus (CCHFV) have been hindered by the lack of immunocompetent animal models. Recently, a lethal nonhuman primate model based on the CCHFV Hoti strain was reported. CCHFV Hoti caused severe...