Obesity Enhances the Conversion of Adipose-Derived Stromal/Stem Cells into Carcinoma-Associated Fibroblast Leading to Cancer Cell Proliferation and Progression to an Invasive Phenotype

Obesity Enhances the Conversion of Adipose-Derived Stromal/Stem Cells into Carcinoma-Associated Fibroblast Leading to Cancer Cell Proliferation and Progression to an Invasive Phenotype

Obesity is associated with enhanced tumor growth and progression. Within the adipose tissue are adipose-derived stromal/stem cells (ASCs) that have been shown to convert into carcinoma-associated fibroblast (CAFs) in the presence of tumor-derived factors. However, the impact of obesity on the ASCs a...

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Main Authors: Amy L. Strong (Author), Dorothy T. Pei (Author), Christian G. Hurst (Author), Jeffrey M. Gimble (Author), Matthew E. Burow (Author), Bruce A. Bunnell (Author)
Format: Book
Published: Hindawi Limited, 2017-01-01T00:00:00Z.
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3rd Floor Main Library

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