Expanding the Structural Diversity of DNA Methyltransferase Inhibitors

• Egile Nagusiak: K. Eurídice Juárez-Mercado (Egilea), Fernando D. Prieto-Martínez (Egilea), Norberto Sánchez-Cruz (Egilea), Andrea Peña-Castillo (Egilea), Diego Prada-Gracia (Egilea), José L. Medina-Franco (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2020-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Inhibitors of DNA methyltransferases (DNMTs) are attractive compounds for epigenetic drug discovery. They are also chemical tools to understand the biochemistry of epigenetic processes. Herein, we report five distinct inhibitors of DNMT1 characterized in enzymatic inhibition assays that did not show...