Safety and immunogenicity of booster vaccination and fractional dosing with Ad26.COV2.S or BNT162b2 in Ad26.COV2.S-vaccinated participants.

• Main Authors: Catherine Riou (Author), Jinal N Bhiman (Author), Yashica Ganga (Author), Shobna Sawry (Author), Frances Ayres (Author), Richard Baguma (Author), Sashkia R Balla (Author), Ntombi Benede (Author), Mallory Bernstein (Author), Asiphe S Besethi (Author), Sandile Cele (Author), Carol Crowther (Author), Mrinmayee Dhar (Author), Sohair Geyer (Author), Katherine Gill (Author), Alba Grifoni (Author), Tandile Hermanus (Author), Haajira Kaldine (Author), Roanne S Keeton (Author), Prudence Kgagudi (Author), Khadija Khan (Author), Erica Lazarus (Author), Jean Le Roux (Author), Gila Lustig (Author), Mashudu Madzivhandila (Author), Siyabulela F J Magugu (Author), Zanele Makhado (Author), Nelia P Manamela (Author), Qiniso Mkhize (Author), Paballo Mosala (Author), Thopisang P Motlou (Author), Hygon Mutavhatsindi (Author), Nonkululeko B Mzindle (Author), Anusha Nana (Author), Rofhiwa Nesamari (Author), Amkele Ngomti (Author), Anathi A Nkayi (Author), Thandeka P Nkosi (Author), Millicent A Omondi (Author), Ravindre Panchia (Author), Faeezah Patel (Author), Alessandro Sette (Author), Upasna Singh (Author), Strauss van Graan (Author), Elizabeth M Venter (Author), Avril Walters (Author), Thandeka Moyo-Gwete (Author), Simone I Richardson (Author), Nigel Garrett (Author), Helen Rees (Author), Linda-Gail Bekker (Author), Glenda Gray (Author), Wendy A Burgers (Author), Alex Sigal (Author), Penny L Moore (Author), Lee Fairlie (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report the safety and immunogenicity of fractional and full dose Ad26.COV2.S and BNT162b2 in an open label phase 2 trial of participants previously vaccinated with a single dose of Ad26.COV2.S, with 91.4% showing evidence of previous SARS-CoV-2 infection. A total of 286 adults (with or without HI...