Cardiac sodium channel inhibition by lamotrigine: In vitro characterization and clinical implications

• المؤلفون الرئيسيون: Lindsey Ingleby‐Talecki (مؤلف), Sven C. vanDijkman (مؤلف), Sean P. Oosterholt (مؤلف), Oscar Della Pasqua (مؤلف), Christina Winter (مؤلف), Marianne Cunnington (مؤلف), Linda Rebar (مؤلف), Sergio Forero‐Schwanhaeuser (مؤلف), Vickas Patel (مؤلف), James A. Cooper (مؤلف), Anthony Bahinski (مؤلف), Khuram W. Chaudhary (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2022-08-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Lamotrigine, approved for use as an antiseizure medication as well as the treatment of bipolar disorder, inhibits sodium channels in the brain to reduce repetitive neuronal firing and pathological release of glutamate. The shared homology of sodium channels and lack of selectivity associate...