Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing

• Main Authors: Christian Dohmen (Author), Thomas Fröhlich (Author), Ulrich Lächelt (Author), Ingo Röhl (Author), Hans-Peter Vornlocher (Author), Philipp Hadwiger (Author), Ernst Wagner (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene silencing mediated by small interfering RNA (siRNA) is a novel approach in the development of new cancer therapeutics. Polycations used for nucleic acid delivery still remain heterogeneous compounds, despite continuous progress in polymer synthetic technologies. Here we report the development o...