An Insight into Giant Cell Arteritis Pathogenesis: Evidence for Oxidative Stress and SIRT1 Downregulation

• Main Authors: Alessandro Ianni (Author), Poonam Kumari (Author), Shahriar Tarighi (Author), Flavia Rita Argento (Author), Eleonora Fini (Author), Giacomo Emmi (Author), Alessandra Bettiol (Author), Thomas Braun (Author), Domenico Prisco (Author), Claudia Fiorillo (Author), Matteo Becatti (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Giant cell arteritis (GCA), medium and large vessel granulomatous vasculitis affecting the elderly, is characterized by a multitude of vascular complications, including venous thrombosis, myocardial infraction and stroke. The formation of granulomatous infiltrates and the enhanced accumulation of pr...