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Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction

Objective: To evaluate longitudinal changes of angiogenic biomarkers in early- (EO-PD) versus late-onset (LO-PD) placental dysfunction. Methods: Serum PlGF and sFlt-1 measured at different intervals in EO-PD (n= 43), LO-PD (n= 31) and controls (n = 133). Results: sFlt-1/PlGF ratio was higher at 16 w...

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Main Authors: Manouk L. E. Hendrix (Author), Kirsten C. M. Palm (Author), Sander M. J. Van Kuijk (Author), Otto Bekers (Author), Marc E. A. Spaanderman (Author), Judith A. P. Bons (Author), Salwan Al-Nasiry (Author)
Format: Book
Published: Taylor & Francis Group, 2019-10-01T00:00:00Z.
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Summary:Objective: To evaluate longitudinal changes of angiogenic biomarkers in early- (EO-PD) versus late-onset (LO-PD) placental dysfunction. Methods: Serum PlGF and sFlt-1 measured at different intervals in EO-PD (n= 43), LO-PD (n= 31) and controls (n = 133). Results: sFlt-1/PlGF ratio was higher at 16 weeks (30.6 vs 17.5), 20 weeks (29.3 vs 8.9) and 30 weeks (16.6 vs 6.7) in EO-PD vs controls (all p< 0.05), but not in LO-PD. Longitudinal changes for all intervals had higher AUC than single measurements. Conclusion: Longitudinal biomarker change between 12 and 30 weeks could improve prediction of EO-PD compared to single measurements.
Item Description:1064-1955
1525-6065
10.1080/10641955.2019.1668948

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