Intracellular Selection of Theophylline-Sensitive Hammerhead Aptazyme

• Main Authors: Qinlin Pu (Author), Shan Zhou (Author), Xin Huang (Author), Yi Yuan (Author), Feng Du (Author), Juan Dong (Author), Gangyi Chen (Author), Xin Cui (Author), Zhuo Tang (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hammerhead ribozyme-based aptazyme (HHAz), inheriting the advantages of small size and high efficiency from the RNA-cleaving ribozyme and the specific recognition ability of aptamers to specific targets, exhibits the huge potential to be a transgene expression regulator. Herein, we report a selectio...