Different Apples, Same Tree: Visualizing Current Biological and Clinical Insights into CTLA-4 Insufficiency and LRBA and DEF6 Deficiencies

• Main Authors: Laura Gámez-Díaz (Author), Markus G. Seidel (Author)
• 格式: 图书
• 出版: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a crucial immune checkpoint that is constitutively expressed in regulatory T (Treg) cells. Following T-cell activation, CTLA-4 is rapidly mobilized from its intracellular vesicle pool to the cell surface to control the availability of co-stimulatory B7 mo...