Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT_1A and D₂ Receptors

• Main Authors: Kinga Sałaciak (Author), Natalia Malikowska-Racia (Author), Klaudia Lustyk (Author), Agata Siwek (Author), Monika Głuch-Lutwin (Author), Grzegorz Kazek (Author), Justyna Popiół (Author), Jacek Sapa (Author), Henryk Marona (Author), Dorota Żelaszczyk (Author), Karolina Pytka (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The increasing number of patients reporting depressive symptoms requires the design of new antidepressants with higher efficacy and limited side effects. As our previous research showed, 2-methoxyphenylpiperazine derivatives are promising candidates to fulfill these criteria. In this study, we aimed...