Finasteride promotes worsening of the cardiac deleterious effects of nandrolone decanoate and protects against genotoxic and cytotoxic damage

• Main Authors: Elizângela Faustino Da Mata (Author), Andrews Marques do Nascimento (Author), Ewelyne Miranda de Lima (Author), Ieda Carneiro Kalil (Author), Denise Coutinho Endringer (Author), Dominik Lenz (Author), Nazaré Souza Bissoli (Author), Girlandia Alexandre Brasil (Author), Tadeu Uggere de Andrade (Author)
• Format: Book
• Published: Universidade de São Paulo, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metabolism of anabolic androgenic steroids is important for its physiological effects. The aim was to investigate the effects of finasteride (a 5α-reductase inhibitor - 5αR) on cardiac and mutagenic effects promoted by ND. Male Wistar rats were separated into three groups: CONT, received the vehicle...