Roles of Human Liver Cytochrome P450 Enzymes in Tenatoprazole Metabolism

• Main Authors: Thien-Kim Le (Author), Young Jin Park (Author), Gun Su Cha (Author), Fikri A. R. Hardiyanti Oktavia (Author), Dong Hyun Kim (Author), Chul-Ho Yun (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tenatoprazole, a newly developed proton pump inhibitor candidate, was developed as an acid inhibitor for gastric acid hypersecretion disorders such as gastric ulcer and reflux esophagitis. It is known that tenatoprazole is metabolized to three major metabolites of 5'-hydroxy tenatoprazole, tena...