Antisense oligonucleotides targeting exon 11 are able to partially rescue the NF2-related schwannomatosis phenotype in vitro

• Главные авторы: Núria Catasús (Автор), Inma Rosas (Автор), Sandra Bonache (Автор), Alex Negro (Автор), Miguel Torres-Martin (Автор), Adrià Plana-Pla (Автор), Hector Salvador (Автор), Eduard Serra (Автор), Ignacio Blanco (Автор), Elisabeth Castellanos (Автор)
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• Опубликовано: Elsevier, 2022-12-01T00:00:00Z.
• Предметы: article
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NF2-related schwannomatosis (NF2-related SWN) is an autosomal dominant condition caused by loss of function variants in the NF2 gene, which codes for the protein Merlin and is characterized by the development of multiple tumors of the nervous system. The clinical presentation of the disease is varia...