Induction of Pluripotent Stem Cells from a Manifesting Carrier of Duchenne Muscular Dystrophy and Characterization of Their X-Inactivation Status

• Main Authors: Yuko Miyagoe-Suzuki (Author), Takashi Nishiyama (Author), Miho Nakamura (Author), Asako Narita (Author), Fusako Takemura (Author), Satoru Masuda (Author), Narihiro Minami (Author), Kumiko Murayama (Author), Hirofumi Komaki (Author), Yu-ichi Goto (Author), Shin'ichi Takeda (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Three to eight percent of female carriers of Duchenne muscular dystrophy (DMD) develop dystrophic symptoms ranging from mild muscle weakness to a rapidly progressive DMD-like muscular dystrophy due to skewed inactivation of X chromosomes during early development. Here, we generated human induced plu...