Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis

• Main Authors: Gavin Tjin (Author), Eric S. White (Author), Alen Faiz (Author), Delphine Sicard (Author), Daniel J. Tschumperlin (Author), Annabelle Mahar (Author), Eleanor P. W. Kable (Author), Janette K. Burgess (Author)
• Format: Book
• Published: The Company of Biologists, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with few effective therapeutic options. Structural remodelling of the extracellular matrix [i.e. collagen cross-linking mediated by the lysyl oxidase (LO) family of enzymes (LOX, LOXL1-4)] might contribute to disease p...