Chapter 14 Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target

In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following cri...

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Bibliographic Details
Main Author: Denton, Helen (auth)
Other Authors: Major, Louise L. (auth), Smith, Terry K. (auth)
Format: Electronic Book Chapter
Language:English
Published: InTechOpen 2013
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